• With tight_layout()

import numpy as np
import matplotlib.pyplot as plt

x=np.linspace(-3,3,100)
y1=np.sin(x)
y2=np.cos(x)
y3=np.tan()
y4=np.exp(x)

fig, ax = plt.subplots(2, 2)

ax[0, 0].plot(x, y1)
ax[0, 1].plot(x, y2)
ax[1, 0].plot(x, y3)
ax[1, 1].plot(x,y4)

ax[0, 0].set_title("Sine function")
ax[0, 1].set_title("Cosine function")
ax[1, 0].set_title("Tangent function")
ax[1, 1].set_title("Exponential function")

fig.tight_layout()
plt.show()

Figures would be placed tightly with proper spaces between them